Articles on tuberculosis

Marva Seifert, Sophia B. Georghiou, Donald Catanzaro, Camilla Rodrigues, Valeriu Crudu, Thomas C. Victor, Richard S. Garfein, Antonino Catanzaro, Timothy C. Rodwell

Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape. Antimicrobial Agents and Chemotherapy 

Georghiou SB, Seifert M,1 Catanzaro D, Garfein RS, Valafar F, Crudu V, Rodrigues C, Victor TC, Catanzaro A, Rodwell TC.   April 2016. Impact Factor: 4.48 · DOI: 10.1128/AAC.00222-16

The impact of mixed infections on the interpretation of molecular epidemiology studies of tuberculosis Replay

Matthias Merker, Valeriu Crudu, Ecaterina Noroc, Elena Romancenco, Christoph Lange. The International Journal of Tuberculosis and Lung Disease 20(3):424-424 · March 2016. Impact Factor: 2.32 · DOI: 10.5588/ijtld.15.1024-2

MTBDRplus and MTBDRsl Assays: The Absence of Wild Type Probe Hybridization and Implications for the Detection of Drug-resistant Tuberculosis

Marva Seifert, Sophia B. Georghiou, Donald Catanzaro, Camilla Rodrigues, Valeriu Crudu, Thomas C. Victor, Richard S. Garfein, Antonino Catanzaro, Timothy C. Rodwell. Journal of clinical microbiology 54(4) · January 2016. Impact Factor: 3.99 · DOI: 10.1128/JCM.02505-15

Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Antimicrobial Cape. Agents and Chemotherapy 

Sophia B. Georghiou, Marva Seifert. 2016 Apr 18. pii: AAC.00222­16.

Multidrug-resistant tuberculosis in Moldova and the Former Yugoslav Republic of Macedonia: The importance of the overall governance of the health systems (Original research)

Thomas-Reilly RG, Tozija F, Soltan V, Nikovska DG, Crudu V, Atun R, McKee M.  SEEJPH 2016, posted: 11 January 2016.DOI 10.4119/UNIBI/SEEJPH-2016-85. DOI: 10.4119/UNIBI/SEEJPH-2016-8

Rapid Drug Susceptibility Testing of Drug Resistant Mycobacterium tuberculosis Directly from Clinical Samples using Amplicon Sequencing

Rebecca E. Colman, Julia Andersona, Darrin Lemmer, Erik Lehmkuhl, Sophia B. Georghiou, Hannah Heatona, Kristin Wigginsa, John D. Gillece, James M. Schupp, Donald G. Catanzaro, Valeriu Crudu, Ted Cohen, Timothy C. Rodwell, David M. Engelthaler. Clin. Microbiol. doi:10.1128/JCM.00535-16

Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis

Antonino Catanzaro1, Timothy C. Rodwell, Donald G. Catanzaro, Richard S. Garfein, Roberta L. Jackson, Marva Seifert, Sophia B. Georghiou, Andre Trollip, Erik Groessl, Naomi Hillery, Valeriu Crudu, Thomas C. Victor, Camilla Rodrigues, Grace ShouYean Lin, Faramarz Valafar, Edward Desmond, Kathleen Eisenach. PLOUSE ONE| DOI:10.1371/journal.pone.0136861 August 31, 2015

Nosocomial transmission of multidrug-resistant tuberculosis

Valeriu Crudu, Matthias Merker, Christoph Lange, Ecaterina Noroc, Elena Romancenco, Dumitru Chesov, Gunar Günther, Stefan Niemann.. JTLD-04-15-0327 2.76 IF

Transmission of mycobacterium tuberculosisUral 16315 lineage causing multidrugresistant tuberculosis among hospitalized patients

Valeriu Crudu, Matthias Merker, Christoph Lange, Ecaterina Noroc, Elena Romancenco, Dumitru Chesov, Gunar Günther, Alaxandru Buga, Sofia Alexandru, Stefan Niemann. Eur Respir J. 2015. Vol. 46 Issue suppl 59. DOI: 10.1183/ 13993003.congress2015. PA2739 Published 1 September 2015 7.13 IF

Predicting differential rifamycin resistance in clinical Mycobacterium tuberculosis isolates by specific rpoB mutations

El Maraachli, M. Slater, Z. L. Berrada, S-Y. G. Lin, A. Catanzaro, E. Desmond, C. Rodrigues, T. C. Victor, V. Crudu, M. T. Gler, T. C. Rodwell. INT J TUBERC LUNG DIS 19(10):000–000. Q 2015. The Union. http://dx.doi.org/10.5588/ijtld.14.0936. 2.76 IF

Novel katG mutations causing isoniazid resistance in clinical tuberculosis isolates

Jessica N Torres, Lynthia V Paul, Timothy C Rodwell, Thomas C Victor, Anu M Amallraja, Afif Elghraoui, Amy Goodmanson, Sarah M Ramirez-Busby, Ashu Chawla, Victoria Zadorozhny, Elizabeth M Streicher, Frederick A Sirgel, Donald Catanzaro, Camilla Rodrigues, Maria Tarcela Gler, Valeru Crudu, Antonino Catanzaro and Faramarz Valafar. Emerging Microbes and Infections (2015) 4, e42; doi:10.1038/emi. 2015.42. IF 2.258

Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing

Rebecca E. Colman, James M. Schupp, Nathan Hicks, David E. Smith, Jordan L. Buchhagen, Paul S. Keim, Faramarz Valafar, Valeriu Crudu, Elena Romancenco, Ecaterina Noroc, Lynn Jackson, Donald Catanzaro, Timothy C. Rodwell, Antonino Catanzaro, David M. Engelthaler. Plos ONE DOI10.1371journal. pone.01266 26 May 13,2015. IF 3.534

Phenotypic and genotypic diversity in a multinational sample of drug-resistant Mycobacterium tuberculosis isolates

Garfein S.,  Catanzaro D. G., . Rodwel T. C,  Avalos E., R. L. Jackson, J. Kaping, H. Evasco, C. Rodrigues, V. Crudu, S-Y. G. Lin, E. Groessel, N. Hillery, A. Trollip, T. Ganiats, T. C. Victor, K. Eisenach, F. Valafar, J. Channick, L. Qian, A. Catanzaro. The International Journal of Tuberculosis and Lung Disease 04/2015; 19(4). DOI:10.5588/ijtld.14.0488 · 2.76 Impact Factor

Multidrug-Resistant Tuberculosis in Europe, 2010–2011

Gunar Günther, Frank van Leth, Sofia Alexandru, Neus Altet, Korkut Avsar, Didi Bang, Raisa Barbuta, Graham Bothamley, Ana Ciobanu, Valeriu Crudu, Manfred Davilovits, Martin Dedicoat, Raquel Duarte, Gina Gualano, Heinke Kunst, Wiel de Lange, Vaira Leimane, Cecile Magis-Escurra, Anne-Marie McLaughlin, Inge Muylle, Veronika Polcová, Emanuele Pontali, Christina Popa, Rudolf Rumetshofer, Alena Skrahina, Varvara Solodovnikova, Victor Spinu, Simon Tiberi, Piret Viiklepp, Christoph Lange and TBNET. Emerging infectious diseases. V. 21, No 3—March 2015. IF-7.327

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Matthias Merker, Camille Blin, Stefano Mona, Nicolas Duforet-Frebourg, Sophie Lecher, Eve Willery, Michael Blum, Sabine Rüsch-Gerdes, Lauren Cowan, James Posey, Igor Mokrousov, Valeriu Crudu, The Global Beijing Diversity Study Group, Philip Supply, Stefan Niemann & Thierry Wirth. Nature Genetics 47, 242–249 (2015) doi:10.1038/ng.3195. IF 29.648

Prognostic significance of novel katG mutations in Mycobacterium tuberculosis

Valafar F., Ramirez-Busby S.M., Torres J., Lynthia V. Paul, Rodwell T.C., Victor T.C., Rodrigues C., Gler M.T., Crudu V., Catanzaro T. Int. J. Mycobacteriol. (2015), http://dx.doi.org/10.1016/j.ijmyco.2014.11.043

Combined antigen-specific interferon-γ and Interleukin-2 release assay (FluoroSpot) for the diagnosis of Mycobacterium tuberculosis infection

Chesov D.PLoSONE 10(3): e0120006. doi:10.1371/journal.pone.0120006. March 18, 2015. IF 3.534

The Global Consortium for Drug-resistant Tuberculosis Diagnostics (GCDD): design of a multi-site, head-to-head study of three rapid tests to detect extensively drug-resistant tuberculosis

Naomi Hillery, Erik J Groessl, Andre Trollip, Donald Catanzaro,Lynn Jackson, Timothy C Rodwell, Richard S Garfein, S-Y Grace Lin, Kathleen Eisenach, Theodore G Ganiats, Daniel Park,Faramarz Valafar, Camilla Rodrigues, Valeriu Crudu, Thomas C Victor, Antonino Catanzaro.Trials 11/2014; 15(1):434. DOI:10.1186/1745-6215-15-434. 2.12 Impact Factor

Evaluation of Pyrosequencing for Detecting Extensively Drug-resistant Tuberculosis (XDR-TB) in Clinical Isolates from Four High-burden Countries

Kanchan Ajbani, Shou-Yean Grace Lin, Camilla Rodrigues,Duylinh Nguyen, Francine Arroyo, Janice Kaping, Lynn Jackson,Richard S Garfein, Donald Catanzaro, Kathleen Eisenach,Thomas C Victor, Valeru Crudu, Maria Tarcela Gler, Nazir Ismail, Edward Desmond, Antonino Catanzaro, Timothy C Rodwell. Antimicrobial Agents and Chemotherapy 11/2014; 59(1). DOI:10.1128/AAC.03614-14 · 4.45 Impact Factor

Management of patients with multidrugresistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

Christoph Lange, Ibrahim Abubakar, Valeriu Crudu, Peter Davies, Martin Dedicoat, Francis Drobniewski, Raquel Duarte, Cordula Ehlers, Connie Erkens, Delia Goletti, Gunar Gu¨nther, Elmira Ibraim, Beate Kampmann, Liga Kuksa, Wiel de Lange, Frank van Leth, Jan van Lunzen, Alberto Matteelli, Dick Menzies, Ignacio Monedero, Elvira Richter, Sabine Ru¨sch-Gerdes, Andreas Sandgren, Anna Scardigli, Alena Skrahina, Enrico Tortoli, Grigory Volchenkov, Dirk Wagner, Marieke J. van der Werf, Bhanu Williams, Wing-Wai Yew, Jean-Pierre Zellweger and Daniela Maria Cirillo for the TBNET. ERJ Expres, March 2014; doi: 10.1183/09031936.00188313. IF 13

High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova

Jenkins HE, Crudu V, Soltan V, Ciobanu A, Domente L, Cohen T. Eur Respir J. 2014 April; 43(4): 1132–1141. doi:10.1183/09031936.00203613. 7.13IF

Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using the MODS assay

A P Trollip, D Moore, J Coronel, L Caviedes, S Klages, T Victor, E Romancenco, V Crudu, K Ajbani, V P Vineet, C Rodrigues, R L Jackson, K Eisenach, R S Garfein, T C Rodwell, E Desmond, E J Groessl, T G Ganiats, A Catanzaro. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 02/2014; 18(2):227-32. DOI: 10.5588/ijtld.13.0229 Impact Factor: 2.61.

Predicting Extensively Drug-resistant Mycobacterium tuberculosis (XDR-TB) Phenotypes with Genetic Mutations

Rodwell TC, Valafar F, Douglas J, Qian L, Garfein RS, Chawla A, Torres J,ZadorozhnyV, Soo Kim M, Hoshide M, Catanzaro D, Jackson L, Lin G, Desmond E, Rodrigues C, Eisenach K, Victor TC, Ismail N, Crudu V, Gle MT, Catanzaro A. 2013. J Clin Microbiol. 2014;52(3):781-9. 4.23 IF

Molecular concepts of macrophage targeting

Fliur Macaev, Veaceslav Boldescu*, Valeriu Crudu, Serghei Pogrebnoi, Marina Zveaghinţeva, Eugenia Stingaci, Natalia Sucman, Vsevolod Pogrebnoi. Chem. J. Mold. 2013, 8(2), 21-31

Geographical differences associated with SNPs in nine gene targets among resistant clinical isolates of mycobacterium tuberculosis

Matt Hoshide, Lishi Qian, Camilla Rodrigues, Rob Warren, Tommie Victor,Henry B Evasco, Thelma Tupasi, Valeriu Crudu, James T Douglas. University of Hawaii, Honolulu, Hawaii. Journal of Clinical Microbiology 06/2013; DOI: 10.1128/JCM.00857-13. 4.16 Impact Factor.

Risk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova

Jenkins HE, Ciobanu A, Plesca V, Crudu V, Galusca I, Soltan V, Cohen T. Int J Tuberc Lung Dis. 2013 Mar; 17(3):373-80. doi: 10.5588/ijtld.12.0464. 76 IF

Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country.

Jenkins HE, Plesca V, Ciobanu A, Crudu V, Galusca I, Soltan V, Serbulenco A, Zignol M, Dadu A, Dara M, Cohen T.  Eur Respir J. 2013 Nov; 42(5):1291-301. doi: 10.1183/09031936.00111812. Epub 2012 Oct 25. IF 7.13

Exogenous reinfection as a major risk factor associated with the spread of drug-resistant TB in hospitals from the country

Crudu ; Stratan E.; Romancenco, E.; Moraru, N.; Turcan N, Domente L, Alexandru S, Niemann S, Rush-Gerdes S, Soltan V, Mosneaga A. Bulletin of the Academy of Science of Republic of Moldova, 4(36) 2012, Chisinau 2012, ISSN 1857-0011.

The new version of molecular genetics methods for detection of tuberculosis and resistance to Rifampicin and Isoniazid

Crudu ; Stratan E.; Romancenco, E.; Moraru, N.; Turcan N.; Allerheiligen V.; Hillemann A. Bulletin of the Academy of Science of Republic of Moldova, 4(36) 2012, Chisinau 2012, ISSN 1857-0011.

First Evaluation of an Improved Assay for Molecular Genetic Detection of Tuberculosis as Well as Rifampin and Isoniazid Resistances

Crudu ; Stratan E.; Romancenco, E.; Moraru, N.; Turcan N.; Allerheiligen V.; Hillemann A. Journal of Clinical Microbiology. 2012, v. 50, nr. 4, 1264–1269. ISSN: 0095-1137. 4.16 Impact Factor.

Aspecte ale instruirii lucrătorilor de asistenta medicală primară în controlul tuberculozei in Moldova

Bivol G., Soltan V, Crudu V, Balteanu L, Vilc V, Ignat R, Nepoliuc L.  Congresul 3 al Medicilor de Familie, 2012

Studierea activității antituberculoase a unor compuși noi sintetizați a tioureidelor acidilui 2-(2-fenetil)-benzoic

Stratan E, Țurcan N, Crudu V, Cotelea T, Moruşciag L Nițulescu G.  Analele USMF 2012.

Study of phenomenon of nosocomial transmission of MDR TB by analyzing genotypic diversity of DNA of tuberculosis strains

Crudu V, Romancenco E, Stratan E, Turcan N, Moraru N, Lesan V, Carchilan L. Bulletin of the Academy of Science of Republic of Moldova, 4(32) 2011, ISSN 1857-0011

The studying of antituberculosis activity of new synthesized compounds of Tioureide Acid 2-(2 – Pheniletil) – Benzoic

Cotelea T., Moruşciag L., Niţulescu G., Chiriţa I., Crudu V., Moraru N., E. Stratan, N. Turcan, E. Romancenco. Bulletin of the Academy of Science of Republic of Moldova, 4(32) 2011, p. 127-130. ISSN 1857-0011.

Increasing tuberculosis case detection: lessons from the Republic of Moldova

Soltan V., Henry A., Crudu V., Zatusevski I. Bulletin of the World Health Organization, January 2008, no.86 (1), p.71-76.

Aspecte de management al diagnosticului microbiologic şi tratamentului tuberculozei multidrogrezistente

Sain D., Crudu V., Râvneac L., Haidarlî I., Crivenco G., Jurja L., Tudos T., Moraru N., Ţîmbalari V, Ciobanu S., Maruşceac I., Nepoliuc L.,  Buletinul Academiei de Ştiinţe a Moldovei Ştiinţe Medicale Revistă Ştiinţifico-Practică. 4(32)/2011; p.27-31.

Organizarea serviciului microbiologic în diagnosticul tuberculozei în cadrul strategiei DOTS. Actualităţi în ftiziopneumologie. Metode de limfologie clinică şi reabilitare endoecologică în pneumologie, ftiziologie şi terapie generală

Crudu V., Moraru N.  Conferinţa ştiinţifico-practică IFP. Chişinău, 2006, vol. 1, p.112-117

Typing of Mycobacterium tuberculosis strains resistant to rifampicin and isoniazid by molecular biological methods

Skotnikova I, E Yu Nosova, O V Markova, OA Irtuganova, V N Krudu, S S Ginda, O V Golishcheva, M N Biryukova, E N Strel’tsova, O V Kalyanina, V I Litvinov, A M Moroz, SA Lapa, DA Gryadunov, V M Mikhailovich.  Bulletin of Experimental Biology and Medicine 10/2003; 136(3):273-5. DOI:10.1023/B:BEBM.0000008981.63290.ef · 0.37

Resistance to antituberculosis drug and practices in drug susceptibility testing in Moldova

Crudu V., Arnatodir T, Laticevschi D.  Int. J. Tuberc.Lung. Dis. 7 (4): 2003, p.336-342

ARTICLES ON TUBERCULOSIS from TB sites

A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis

G.B. Migliori, B. Eker, M.D. Richardson, G. Sotgiu, J-P. Zellweger, A. Skrahina, J. Ortmann, E. Girardi, H. Hoffmann, G. Besozzi, N. Bevilacqua, D. Kirsten, R. Centis and C. Lange for the TBNET Study Group

Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis

Giovanni Sotgiu, Rosella Centis, Lia D’Ambrosio, Jan-William C. Alffenaar, Holly A. Anger, Jose A.Caminero, PaoloCastiglia, SaverioDe Lorenzo,Giovanni Ferrara, Won-Jung Koh, Giesela F. Schecter, Tae S. Shim, Rupak Singla, Alena Skrahina, Antonio Spanevello, Zarir F. Udwadia, Miquel Villar, Elisabetta Zampogna, Jean-Pierre Zellweger, Alimuddin Zumla and Giovanni Battista Migliori

Health care index score and risk of death following tuberculosis diagnosis in HIV-positive patients

D. N. Podlekareva, D. Grint, F. A. Post, A. Mocroft, A. M. Panteleev, R. F. Miller, J. M. Miro, M. Bruyand, H. Furrer, V. Riekstina, E. Girardi, M. H. Losso, J. A. Caylá, E. A. Malashenkov, N. Obel, A. M. Skrahina, J. D. Lundgren, O. Kirk; HIV-TB Study Group

Linezolid to treat extensively drug- resistant TB: retrospective data are confirmed by experimental evidence

Giovanni Sotgiu, Rosella Centis, Lia D’Ambrosio, Antonio Spanevello and Giovanni Battista Migliori on behalf of the International Group for the study of Linezolid

Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

Christoph Lange, Ibrahim Abubakar, Jan-Willem C. Alffenaar, Graham Bothamley, Jose A. Caminero, Anna Cristina C. Carvalho, Kwok-Chiu Chang, Luigi Codecasa, Ana Correia, Valeriu Crudu, Peter Davies, Martin Dedicoat, Francis Drobniewski, Raquel Duarte, Cordula Ehlers, Connie Erkens, Delia Goletti, Gunar GЁunther, Elmira Ibraim, Beate Kampmann, Liga Kuksa, Wiel de Lange, Frank van Leth, Jan van Lunzen, Alberto Matteelli, Dick Menzies, Ignacio Monedero, Elvira Richter, Sabine RЁusch-Gerdes, Andreas Sandgren, Anna Scardigli, Alena Skrahina, Enrico Tortoli, Grigory Volchenkov, Dirk Wagner, Marieke J. van der Werf, Bhanu Williams, Wing-Wai Yew, Jean-Pierre Zellweger and Daniela Maria Cirillo for the TBNET

Multi-drug-resistant tuberculosis in HIV positive patients in Eastern Europe

Frank A. Post, Daniel Grint, Anne Marie Werlinrud, Alexander Panteleev, Vieja Riekstina, Evgeniy A. Malashenkov, Alena Skrahina, Dan Duiculescu, Daria Podlekareva, Igor Karpov, Vasiliy Bondarenko, Nelly Chentsova, Jens Lundgren, Amanda Mocroft, Ole Kirk, Jose Miro, for the HIV-TB Study Group

Mortality from HIV and TB coinfections is higher in Eastern Europe than in Western Europe and Argentina

The HIV/TB Study Writing Group

Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe

Daria N. Podlekareva, Alexander M. Panteleev, Daniel Grint, Frank A. Post, Jose M. Miro, Mathias Bruyand, Hansjakob Furrer, Niels Obel, Enrico Girardi, Anna Vasilenko, Marcelo H. Losso, Alejandro Arenas-Pinto, Joan Caylґa, Aza Rakhmanova, Indra Zeltina, Anne Marie Werlinrud, Jens D. Lundgren, Amanda Mocroft, Ole Kirk and the HIV/TB study group

Targeting multidrug-resistant tuberculosis (MDR-TB) by therapeutic vaccines

Satria A. Prabowo, Matthias I. Gröschel, Ed D. L. Schmidt, Alena Skrahina, Traian Mihaescu, Serap Hastürk, Rotislav Mitrofanov, Edita Pimkina, Ildikó Visontai, Bouke de Jong, John L. Stanford, Père-Joan Cardona, Stefan H. E. Kaufmann, Tjip S. van der Werf